Francis AN, Seidman LJ, Jabbar GA, Mesholam-Gately R, Thermenos HW, Juelich R, Proal AC, Shenton M, Kubicki M, Mathew I, et al. Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia. Schizophr Res. 2012;141(1):65–71.
Abstract
INTRODUCTION: Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental abnormalities associated with genetic risk for the illness. The anatomical pathways for language are hypothesized to be abnormal and to underlie the positive symptoms of schizophrenia. Examining non-psychotic relatives at high familial risk (FHR) for schizophrenia may clarify if these deficits represent trait markers associated with genetic vulnerability, rather than specific markers resulting from the pathological process underlying schizophrenia.
Last updated on 02/26/2023