Makris N, Liang L, Biederman J, Valera EM, Brown AB, Petty C, Spencer TJ, Faraone S V, Seidman LJ. Toward Defining the Neural Substrates of ADHD: A Controlled Structural MRI Study in Medication-Na ıve Adults. J Atten Disord. 2015;19(11):944–53.
Abstract
OBJECTIVE: We assessed the neural correlates of adult ADHD in treatment-na ıve participants, an approach necessary for identifying neural substrates unconfounded by medication effects. METHOD: The sample consisted of 24 medication-na ıve adults with Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) diagnosed ADHD and 24 healthy controls, comparable on age, sex, handedness, reading achievement, IQ, and psychiatric comorbidity. All participants were assessed with structured diagnostic interviews. Magnetic resonance imaging (MRI)-based regional voxel-based morphometry (r-VBM) was used to assess volumetric differences in a priori defined brain regions of interest. RESULTS: VBM analysis revealed group differences in the hypothesized cortical and subcortical areas; however, only cerebellar volume reductions in ADHD retained significance (p .05) after corrections for multiple comparisons. CONCLUSION: These results support the notion that medication-na ıve ADHD as expressed in adulthood, manifests subtle brain volume reductions from normal in the cerebellum, and possibly in other syndrome-congruent gray-matter structures. Larger samples are required to confirm these findings.
Last updated on 02/26/2023