Mulert C, Kirsch V, Whitford TJ, Alvarado J, Pelavin P, McCarley RW, Kubicki M, Salisbury DF, Shenton ME. Hearing voices: a role of interhemispheric auditory connectivity?. World J Biol Psychiatry. 2012;13(2):153–8.
Abstract
OBJECTIVES: Auditory verbal hallucinations (AVH) are among the most common symptoms in schizophrenia. Earlier studies suggest changes in the structural connectivity of auditory areas involved in the pathophysiology of auditory hallucinations. Combining diffusion tensor imaging (DTI) and fibre tractography provides a unique opportunity to visualize and quantify entire fibre bundles. METHODS: Fibre tracts connecting homotopic auditory areas via the corpus callosum were identified with DTI in ten first episode paranoid schizophrenia patients and ten healthy controls. Regions of interest were drawn manually, to guide tractography, and fractional anisotropy (FA) - a measure of fibre integrity - was calculated and averaged over the entire tract for each subject.
Last updated on 02/26/2023