Nystedt J, Nilsson M, Jönsen A, Nilsson P, Bengtsson A, Lilja \r A, Lätt J, Mannfolk P, Sundgren PC. Altered white matter microstructure in lupus patients: a diffusion tensor imaging study. Arthritis Res Ther. 2018;20(1):21.
Abstract
BACKGROUND: The purpose of this study was to investigate whether white matter microstructure is altered in patients suffering from systemic lupus erythematosus (SLE), and if so, whether such alterations differed between patients with and without neuropsychiatric symptoms. METHODS: Structural MRI and diffusion tensor imaging (DTI) were performed in 64 female SLE patients (mean age 36.9 years, range 18.2-52.2 years) and 21 healthy controls (mean age 36.7 years, range 23.3-51.2 years) in conjunction with clinical examination, laboratory tests, cognitive evaluation, and self-assessment questionnaires. The patients were subgrouped according to the American College of Rheumatology Neuropsychiatric Systemic Lupus Erythematosus case definitions into non-neuropsychiatric SLE (nonNPSLE) and neuropsychiatric SLE (NPSLE).
Last updated on 02/26/2023