Nery F, Szczepankiewicz F, Kerkelä L, Hall MG, Kaden E, Gordon I, Thomas DL, Clark CA. In vivo demonstration of microscopic anisotropy in the human kidney using multidimensional diffusion MRI. Magn Reson Med. 2019;82(6):2160–2168.
Abstract
PURPOSE: To demonstrate the feasibility of multidimensional diffusion MRI to probe and quantify microscopic fractional anisotropy (µFA) in human kidneys in vivo. METHODS: Linear tensor encoded (LTE) and spherical tensor encoded (STE) renal diffusion MRI scans were performed in 10 healthy volunteers. Respiratory triggering and image registration were used to minimize motion artefacts during the acquisition. Kidney cortex-medulla were semi-automatically segmented based on fractional anisotropy (FA) values. A model-free analysis of LTE and STE signal dependence on b-value in the renal cortex and medulla was performed. Subsequently, µFA was estimated using a single-shell approach. Finally, a comparison of conventional FA and µFA is shown.
Last updated on 02/26/2023