A Robust Algorithm for Fiber-Bundle Atlas Construction

Ulas Ziyan, Mert R. Sabuncu, W. Eric. L. Grimson, C.-F. Westin
Mathematical Methods in Biomedical Image Analysis (MMBIA 2007): 2007 IEEE Workshop
Pages
October, 2007

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Abstract

integrated registra- tion and clustering algorithm to compute an atlas of fiber- bundles from a set of multi-subject diffusion weighted MR images. We formulate a maximum likelihood problem which the proposed method solves using a generalized Expectation Maximization (EM) framework. Additionally, the algorithm employs an outlier rejection and denoising strategy to pro- duce sharp probabilistic maps of certain bundles of interest. This map is potentially useful for making diffusion measure- ments in a common coordinate system to identify pathology related changes or developmental trends.

Isoprobability surfaces of the spatial distributions of Fornix (in green) and Cingulum (in purple) bundles constructed from 15 subjects using the EM algorithm with tract cut operations. A few selected tracts from Corpus Callosum (in black) are also drawn to highlight the spatial proximity of the three bundles. These spatial distributions retain very little of the tractography noise that is apparent in the individuals� tract bundles.

Reference

Ziyan U, Sabuncu MR, Grimson WEL, Westin CF. A robust algorithm for fiber-bundle atlas construction. In Mathematical Methods in Biomedical Image Analysis (MMBIA 2007): 2007 IEEE Workshop, ICCV 2007 workshop. Rio de Janeiro, Brazil, 2007;.

Bibtex entry

@InProceedings{ziyanMMBIA07,
  author         = "Ulas Ziyan and Mert R. Sabuncu and W. Eric. L. Grimson and 
                   Carl-Fredrik Westin",                                       
  title          = "A Robust Algorithm for Fiber-Bundle Atlas Construction",   
  booktitle      = "Mathematical Methods in Biomedical Image Analysis (MMBIA   
                   2007): 2007 IEEE Workshop",                                 
  month          = "October",                                                  
  year           = "2007",                                                     
  series         = {ICCV 2007 workshop},                                       
  pages          = "",                                                         
  address        = "Rio de Janeiro, Brazil",}

Grants

NIH U54-EB005149 (NAMIC), NIH P41-RR13218 (NAC), NIH R01-MH074794, NIH R01-NS051826, NIH R01-AG20012, NIH P41-RR15241