A High-Dimensional Fiber Tract Atlas

L. O'Donnell, C.-F. Westin
Proceedings of the ISMRM Annual Meeting (ISMRM'06)
Pages 1
May, 2006

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Abstract

We present a method for creation of an atlas of major white matter fiber tracts. Using spectral clustering, we automatically find many small fiber clusters in a population of subjects. The atlas thus takes the form of cluster centroids in the high-dimensional spectral embedding space. In this space, fiber tracts may be subdivided into multiple clusters, which then are manually labeled and grouped into anatomically meaningful entities, defining an atlas. In general, comparison of information across clusters from different brains is not straightforward, since the basis vectors defining the respective embedded spaces are different. Here we describe a way to transfer this embedded atlas information to a new subject via the Nystrom method [3], and we demonstrate the resulting tract labels on a new subject.

Clusters from the five atlas brains are shown on the left followed by the new subject on the right. All 100 clusters are shown in the top row, followed by the uncinate fasciculi and cingulum bundles in the second and third rows.

Reference

O'Donnell L, Westin CF. A high-dimensional fiber tract atlas. In Proceedings of the ISMRM Annual Meeting (ISMRM'06). Seattle, USA, 2006;1.

Bibtex entry

@InProceedings{odonnellISMRM06,
  author         = {L. O'Donnell and C.-F. Westin},                            
  title          = {A High-Dimensional Fiber Tract Atlas},                     
  booktitle      = {Proceedings of the {ISMRM} Annual Meeting (ISMRM'06)},     
  year           = {2006},                                                     
  pages          = {1},                                                        
  address        = {Seattle, USA},                                             
  month          = {May}
}

Grants

NIH P41-RR13218 (NAC), NIH R01-NS051826, NIH U24-RR021382, NIH U54-EB005149 (NAMIC)