Fiber Bundle Estimation and Parameterization

M. Niethammer, S. Bouix, C.-F. Westin, M. E. Shenton
Ninth International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI'06)
Pages 252-259
October, 2006

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Abstract

Individual white matter fibers cannot be resolved by current magnetic resonance (MR) technology. Many fibers of a fiber bundle will pass through an individual volume element (voxel). Individual visualized fiber tracts are thus the result of interpolation on a relatively coarse voxel grid, and an infinite number of them may be generated in a given volume by interpolation. This paper aims at creating a level set representation of a fiber bundle to describe this apparent continuum of fibers. It further introduces a coordinate system warped to the fiber bundle geometry, allowing for the definition of geometrically meaningful fiber bundle measures.

Figs. 5(a) and 5(d) show the boundaries of the traced cingulum bundle and the corona radiata (i.e., the envelopes of X R(y(x))) overlayed on a sagittal brain slice respectively. Fig. 5(e) shows the arclength isosurfaces for the corona radiata. Figs. 5(b) and 5(f) show the respective arclength isosurfaces after reseeding for the cingulum bundle and the corona radiata. Reseeding improved the tracing result. Fig. 5(c) shows a zoom on one of the arclength isosurfaces of the cingulum bundle. It highlights the uneven distribution of streamlines passing through. Statistical quantities based on values computed at the locations of the intersection points of the streamlines with the arclength isosurface can now be replaced by integration over the arclength isosurface itself, removing potential bias towards more densely sampled areas.

Reference

Niethammer M, Bouix S, Westin CF, Shenton ME. Fiber bundle estimation and parameterization. In Ninth International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI'06), Lecture Notes in Computer Science 4191. Copenhagen, Denmark, 2006;252-259.

Bibtex entry

@InProceedings{niethammerMICCAI06,
  author         = "Marc Niethammer and Sylvain Bouix and Carl-Fredrik Westin  
                   and  Martha E. Shenton",                                    
  title          = "Fiber Bundle Estimation and Parameterization",             
  booktitle      = "Ninth International Conference on Medical Image Computing  
                   and Computer-Assisted Intervention (MICCAI'06)",            
  month          = "October",                                                  
  year           = "2006",                                                     
  pages          = "252--259",                                                 
  series         = "Lecture Notes in Computer Science 4191",                   
  address        = "Copenhagen, Denmark"}

Grants

NIH R01-MH50747, NIH K05-70047, NIH U54-EB005149 (NAMIC)

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