Cingulate Fasciculus Integrity Disruption in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study

M. Kubicki, C.-F. Westin, S. E. Maier, H. Mamata, M. Frumin, H. Ernst-Hirshefeld, R. Kikinis, F. A. Jolesz, R. W. McCarley, M. E. Shenton
Biological Phychiatry
Volume 54, Pages 1171-1180
2003

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Abstract

Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), the white matter tract furnishing both input and output to CG, and the most prominent white matter fiber tract in the limbic system, has not been evaluated in schizophrenia using the new technology of diffusion tensor imaging (DTI). We used line scan DTI to evaluate diffusion in the CB in 16 male schizophrenia patients and 18 male control subjects, group-matched for age, parental socioeconomic status, and handedness. We acquired 4-mmthick coronal slices through the entire brain. Maps of fractional anisotropy (FA) were generated to quantify diffusion within the left and right CB on eight slices that included the central portion of the CB.

Left image represents diffusion tensor image of one of the eight slices used for the measurements. Right side illustrates the threshold applied to the diffusion tensor images, to define the cingulum bundle (arrows, see description in the text).
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Reference

Kubicki M, Westin CF, Maier SE, Mamata H, Frumin M, Ernst-Hirshefeld H, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study. Biological Phychiatry 2003;54:1171-1180.

Bibtex entry

@Article{kubickiBiologPsych03,
  author         = {M. Kubicki and C.-F. Westin and S. E. Maier and H. Mamata  
                   and  M. Frumin and H. Ernst-Hirshefeld and R. Kikinis and F.
                   A Jolesz  and R. W. McCarley and M. E. Shenton},            
  title          = {Cingulate Fasciculus Integrity Disruption in Schizophrenia:
                    A Magnetic Resonance Diffusion Tensor Imaging Study},      
  journal        = {Biological Phychiatry},                                    
  year           = {2003},                                                     
  volume         = {54},                                                       
  pages          = {1171--1180}
}

Grants

NIH P41-RR13218 (NAC), NIH K02-MH01110, NIH R01-MH50747, NIH R01-MH40799, NIH R01-NS39335, NIH R01-RR11747, NIH P41-RR13218 (NAC)

Research areas

DTMRI, Tensor

Copyright Information

Society of Biological Psychiatry