Bias in Resampling-Based Thresholding of Statistical Maps in fMRI


O. Friman, C.-F. Westin
Seventh International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI'04)
Pages 687-694
September, 2004

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Abstract

Selecting a threshold for the statistical parameter maps in functional MRI (fMRI) is a delicate matter. The use of advanced test statistics and/or the complex dependence structure of the noise may preclude parametric statistical methods for finding appropriate thresholds. Non-parametric statistical methodology has been presented as a feasible alternative. In this paper we discuss resampling-based methods for finding ing thresholds and show that proposed non-parametric approaches can lead to severely biased results.

A slice in the real fMRI data set subjected to the thresholds in Table 1. Note the difference between using the thresholds obtained by resampling original data and those obtained by resampling residual data.


Reference

Friman O, Westin CF. Bias in resampling-based thresholding of statistical maps in fMRI. In Seventh International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI'04), Lecture Notes in Computer Science. Rennes - Saint Malo, France, 2004;687-694.

Bibtex entry

@InProceedings{frimanMICCAI04,
  author         = {O. Friman and C.-F. Westin},                               
  title          = {Bias in Resampling-Based Thresholding of Statistical Maps  
                   in {fMRI}},                                                 
  booktitle      = {Seventh International Conference on Medical Image Computing
                   and  Computer-Assisted Intervention (MICCAI'04)},           
  series         = {Lecture Notes in Computer Science},                        
  pages          = {687--694},                                                 
  year           = {2004},                                                     
  address        = {Rennes - Saint Malo, France},                              
  month          = {September}
}                                                

Grants

NIH P41-RR13218 (NAC), CIMIT

Research area

fMRI

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